Home' Spa and Clinic : Volume 62 July 2015 Contents In a nutshell, GF are proteins that
regulate cellular growth, cell turnover and
help to heal and repair the skin.
They are secreted by all cell types in the
body, binding to receptors on cell surfaces
stimulating their function and influencing
But it is a far cry from the role
microbially engineered GF (from plants or
bacteria) play in skincare formulations.
They act directly as stimulants over cell
division, by either interacting directly with
the genes or stimulating the secretion of a
cell’s own GFs to achieve the same benefit –
but they DO NOT affect DNA sequence.
When the natural production of
GF, as well as DNA repair enzymes, is
compromised, it contributes to some of the
more obvious ageing effects such as dryness,
dullness in tone, discolouration and age
spots, fine lines and wrinkles and overall
loss of radiance and resiliency.
“Growth factors, when formulated in
stable, high concentrations have been
shown in controlled studies to stimulate
neocollagenesis [formation of new
collagen], which correlates with clinical
improvement in lines and wrinkles, and skin
tone and texture,” says US dermatologist Dr
Hema Sundarum, who presented at NSS.
“ These blinded, vehicle- controlled
studies were performed on SkinMedica TNS
products, which contain physiologically
balanced growth factors.”
Aforementioned Dr Ronald Moy is the
founder of DNA Renewal skincare, a high-
performance range that was developed from
years of research.
He and scientific colleagues recently
published a paper with the results of a
clinical trial re the use of GFs on the
vulnerable skin around the eyes, often the
first to manifest signs of ageing and damage.
“ W ith age, lower eyelid skin laxity leads
to a feature referred to commonly as under-
eye bags,” Dr Moy says.
“As a result, we performed a clinical trial
[published in April 2015 in the Journal of
Drugs in Dermatology] using a synthetic,
barley-derived GF to investigate its effect
on the appearance of under-eye bags in 18
volunteers (13 women, 5 men, mean age 52).
“Subjects applied GF serum to the
infraorbital area twice daily for 12 weeks.
Sixteen completed the trial. All but two
subjects reported improvement at the final
visit; improvement being quantified as 76-
100 percent by two subjects, 50-75 percent by
three subjects, and 25-49 by nine subjects.
“ The ability of GF to increase dermal
collagen explains the reduced appearance
of under-eye bags in our study. Of note,
many of the subjects in our study said they
noticed an improvement in infraorbital
Stephanie Sherlock, CEO of medical
dev ice and technology distributor
Avention Global, says their Da Vinci (for
skin rejuvenation) and Factor 6 (for hair
regrowth) formulas contain dramatically
more GF than the body naturally produces.
“ The body normally produces 127 ng/
ml worth of GF on its own where there are
10,000 -21,000 ng/ml of GF in Avention’s
skin and hair serums,” she says.
They are produced using a unique,
patented process to grow natural, organic
proteins on e- coli and then “fold” them into
the shapes of specific growth factors.
“E -coli is a bacteria commonly found
on the body and used in pharmaceutical,”
says Stephanie. “Medical growth factors
are grown with e-coli bacteria, not plant or
“Da Vinci 21 [the professional use
serum] has five growth factors with a
concentration of 21,000ng/ml and the
molecular size means it can only be
delivered through professional treatments
during microneedling,” says Stephanie.
“Da Vinci 10 serum has a molecular size
that can be absorbed by the skin at home to
maintain and boost results, also containing
five growth factors with a concentration of
“ This compares with on average 127
ng/ml of growth factor produced by PRP
(Platelet Rich Plasma) treatments that cost
up to five times more.”
Skin therapist Lauren Broughton, of
Sydney’s renowned Gillian Adams Salon and
Spa, reports remarkable results with Da Vinci.
“One client particularly stands out,” says
Lauren. “She came to us with deep pitted
FOR SPACE REASONS, WE UNFORTUNATELY CAN’T DO JUSTICE TO ALL
THE SUPERIOR SKINCARE BRANDS THAT SPA+CLINIC RECOMMENDS
WHOSE PRODUCTS AND TREATMENTS PROMOTE SKIN DNA REPAIR. FOR A
COMPREHENSIVE LIST PLEASE VISIT SPACLINIC.COM.AU/CURRENT ISSUE
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